SYNTHESIS AND CHARACTERISATION OF
CHOLINESTERASE REVERSIBLE INHIBITORS SYNTHONES. MO INVESTIGATION OF CHARGES ON
PYRIDINIC MOIETY OF MOLECULES.
Branko J. Drakulić, Institute
of Chemistry, Technology and Metallurgy, University of Belgrade
Maja D. Vitorović-Todorović, Military-Technical Institute, Belgrade
Abstract – Syntheses and
characterization of five compounds (1-5) that can be further functionaized to
afford dual reversible ChE inhibitors; the enzyme that hydrolyses ACh on
neuromuscular junctions. Mentioned compounds and their derivates probably could
be used as prophylactic agents for OP chemical warfare agent’s intoxication.
Semiempirical MO calculations on central moiety of molecules are described.
Keywords: Acetylcholinesterase inhibition, Tacrine derivatives, molecular-orbital calculations.
КОМПЛЕТАН РАД