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ISSN: 1820-0206 First published in 1950
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doi: 10.5937/str1903015A Vol. 69, No.3 (2019), Pages: 15-29
Esters of Organophosphorus Acids - Toxicity, Application and Removal from the Environment
Vladan J. Anićijević Tamara D. Lazarević-Pašti Dragana D. Vasić Anićijević Radovan M. Karkalić
Esters of organophosphorus acids (OPs) are widely used nowadays. They have an application as pesticides, drugs or chemical warfare agents. Their acute toxicity is ascribed to the inhibition of acetylcholinesterase (AChE), a key enzyme in the transmission of nerve impulses in mammals. Their toxic effects are manifested by the accumulation of acetylcholine and can lead to the paralysis or death. OPs poisoning therapy is based on the application of specific antidotes as well as non-specific and symptomatic procedures. In this contribution, recent achievements concerning the protection from OPs activity and an overview of the methods for their removal from the environment and decontamination of contaminated persons were presented Key words: esters of organophosphorus acids, pesticides, nerve agents, toxicity, environment, remediation
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